GREEN CHEMISTRY Syllabus

GREEN CHEMISTRY 

Delhi University

Here is the syllabus of Green Chemistry Delhi University 
(Credit Cousre of B.Sc. Stream)

Link to Downloadable Format Syllabus.docx

Delhi University

02 December 2011           Bsc (H) Credit Course and Bsc Analytic Chemistry

EL 310 (i) GREEN CHEMISTRY

With the environmental concern and shrinking resources acquiring enormous proportions, it has become imperative to devise safer alternative materials and technology that would ensure the human sustenance. This course intends to take the students through the newer, environment friendly products and procedures and incite them to take a more holistic view of different chemical processes.

Unit l    Introduction to Green Chemistry

What is Green Chemistry? Need for Green Chemistry. Goals of Green Chemistry. Limitations/Obstacles in the pursuit of the goals of Green Chemistry.

Unit II  Principles of Green Chemistry and Designing a Chemical  synthesis

  Twelve principles of Green Chemistry with their explanations and examples; Designing a Green Synthesis using these  principles; Prevention of Waste/byproducts; maximum incorporation of the materials used in the process into the final products (Atom Economy); prevention/minimization of hazardous/toxic products; designing safer chemicals  –  different basic approaches to do  so; selection of appropriate auxiliary substances (solvents, separation agents), green solvents, solventless processes, immobilized solvents and ionic liquids; energy requirements for reactions  -   use of microwaves, ultrasonic energy; selection of starting materials; avoidance of unnecessary  derivatization  –  careful  use of blocking/protectinggroups; use of catalytic reagents (wherever possible) in preference to stoichiometric reagents; designing of biodegradable products; prevention of chemical accidents;  strengthening/development of analytical techniques to prevent and minimize the generation of hazardous substances in chemical processes.

 

Unit III  Examples of Green Synthesis/Reactions

1  Green Synthesis of the following compounds: adipic acid, catechol, BHT, methyl methacrylate, urethane, aromatic amines (4-aminodiphenylamine), benzyl bromide, acetaldehyde, disodium iminodiacetate (alternative to strecker synthesis), citral,  ibuprofen, paracetamol, turtural. (furfural)

 2  Microwave assisted reactions in water: Hofmann Elimination, Hydrolysis (of benzyl chloride, benzamide, n-phenyl benzamide, methylbenzoate to benzole acid), Oxidation (of toluene, alcohols).  Microwave assisted reactions in organic solvents: Esterification, Fries rearrangement,  Orthoester Claisen Rearrangement,  Diels Alder Reaction,  Decarboxylation. Microwave  assisted solid state reactions: Deacetylation, Deprotection. Saponification of esters, Alkylation of reactive methylene compounds,  reductions, synthesis of nitriles from aldehydes; anhydrides from dicarboxylic acid; pyrimidine and pyridine derivatives; 1,2-dihydrotriazine derivatives; benzimidazoles.

 3   Ultrasound assisted reactions: Esterification, saponification, substitution reactions, Alkylations, oxidation, reduction,  coupling reaction, Cannizaro  reaction, Strecker synthesis, Reformatsky reaction.

 4  Selective methylation of active methylene group using dimethylcarbonate: Solid-state polymerization of amorphous polymers using diphenylcarbonate; Use of   “Clayan”, a non-metallic oxidative reagent for various reactions; Free Radical Bromination; Role of Tellurium in Organic Syntheses; Biocatalysis in Organic Syntheses.

 

Unit IV Future Trends in Green Chemistry

Oxidation reagents and catalysts;  Biomimetic, multifunctional reagents; Combinatorial green  chemistry; Proliferation of solventless reactions; oncovalent derivatization;  Green chemistry in sustainable development.

Suggested Readings:

1.  V.K.  Ahluwalia &  M.R.  Kidwai:  New Trends in Green Chemistry, Anamalaya Publishers (2005).

2.  P.T.  Anastes  &  J.K. Warmer: Oxford Green Chemistry-  Theory and Practical, University Press (1998).

3.  A.S. Matlack: Introduction to Green Chemistry, Marcel Deckkar, (2001).

4.  M.C.  Cann  &  M.E.  Connely:  Real-World cases in Green Chemistry, American Chemical Society, Washington (2000).

5.  M.A. Ryan & M. Tinnesand,  Introduction to Green Chemistry, American Chemical Society, Washington (2002).